Ryan Newman is perhaps best known for her role in the 2006 action comedy Zoom. In the film, she plays Cindy Collins, a six-year-old girl with super strength who is trying to save the world. In the comedy, Newman co-stars with Tim Allen, Courtney Cox, and Chevy Chase. In 2007 Newman was nominated for a Young Artist Award for her role.

Newman has the distinction of being the youngest actor ever to be motion captured for the Robert Zemeckis and Steven Spielberg animated film Monster House, which was released in 2006. In the film, three kids discover the truth behind a creepy and mysterious house. Among others, Newman was part of a cast compiled of Steve Buscemi, Nick Cannon, Maggie Gyllenhaal, Kevin James, Jason Lee, and Catherine O'Hara.

In addition to films, Newman has been seen in two Hannah Montana episodes as a young Miley Stewart, namely Smells Like Teen Sellout, and I Am Hannah, Hear Me Croak. She has worked with both Billy Ray Cyrus and Brooke Shields. Her latest film is a comedy released in 2008 called Lower Learning with Jason Biggs. In early 2009, Newman landed a minor role in the Disney XD show, Zeke and Luther, portraying Ginger.

Currently, Newman resides in southern California with her parents and older sister, Jessica. Her hobbies include gymnastics, hip hop dancing, singing, and playing with her American Girl dolls.